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Anti-PTEN (R159S) Mouse Monoclonal Antibody

价格¥4800.00
品牌NewEastBio   
产地美国
货号26313
规格100ul
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  • PTEN (R159S)

    Catalog Number: 26313

    Gene Symbol: PTEN, 10q23del, BZS, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, MMAC1, PTEN1, TEP1

    Description: Anti-PTEN (R159S) Mouse Monoclonal Antibody




    Background: Phosphatase and tensin                            

    homolog (PTEN) was identified as a 

    tumor suppressor that is mutated in a 

    large number of cancers at high 

    frequency. It is one of the most commonly 

    lost tumor suppressors in human cancer. 

    During tumor development, mutations and 

    deletions of PTEN occur that inactivate its 

    enzymatic activity leading to increased cell 

    proliferation and reduced cell death. 

    Frequent genetic inactivation of PTEN occurs 

    in glioblastoma, endometrial cancer, and 

    prostate cancer; and reduced expression is 

    found in many other tumor types such as 

    lung and breast cancer.

    Immunogen: A synthetic peptide from the 

    internal region of PTEN which includes the 

    mutation of R159S, human origin.

    Tested applications: ELISA, WB

    Recommended dilutions:

    ELISA:  1:1000-1:5000

    WB:     1:500-1:1000

    IHC:     1:50-1:100

    Concentration: 1 mg/ml

    Host: Mouse

    Clonality: Monoclonal

    Purity: Purified from ascites

    Format: Liquid

    Storage buffer: 

    Preservative: no

    Constituents: PBS (without Mg2+ and Ca2+), 

    pH 7.4, 150 mM NaCl, 50% glycerol

    Species Reactivity: Recognizes EGFR 

    (L747-P753) S, but not wild type EGFR 

    protein from vertebrates.

    Storage Conditions: Store at -20°C. Avoid 

    freeze / thaw cycles.


    Western blot:  

    360截图20191120124055745.jpg




    Western blot analysis of recombinant PTEN 

    (R159S) and wildtype proteins. Purified 

    His-tagged FGFR1 (R159S) protein (lane 2) and 

    corresponding wildtype protein (lane 1) were 

    blotted with anti-PTEN (R159S) monoclonal 

    antibody (Cat. #26313). Anti-PTEN (R159S) 

    Mouse Monoclonal Antibody




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